Mo City Radio was founded in 2020 by Johnnie Jackson, affectionately known as Mo City Jay, with the vision of creating a platform that celebrates local talent and provides high-quality entertainment for the community. Initially broadcasting from a small home studio, the station quickly gained popularity, prompting a move to its current location in 2021 to accommodate growing demand. In 2024, Mo City Radio partnered with MoSerious Entertainment, expanding its reach and capabilities to include podcasting, studio rentals, and a larger slate of live programming. Today, Mo City Radio continues to thrive as a central hub for music, talk shows, and community engagement.